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Research ArticleNeuroimaging Physics/Functional Neuroimaging/CT and MRI Technology

Diffusion-Weighted Imaging Reveals Impaired Glymphatic Clearance in Idiopathic Intracranial Hypertension

Derrek Schartz, Alan Finkelstein, Nhat Hoang, Matthew T. Bender, Giovanni Schifitto and Jianhui Zhong
American Journal of Neuroradiology February 2024, 45 (2) 149-154; DOI: https://doi.org/10.3174/ajnr.A8088
Derrek Schartz
aFrom the Department of Imaging Sciences (D.S., A.F., N.H., G.S., J.Z.), University of Rochester Medical Center, Rochester, New York
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  • ORCID record for Derrek Schartz
Alan Finkelstein
aFrom the Department of Imaging Sciences (D.S., A.F., N.H., G.S., J.Z.), University of Rochester Medical Center, Rochester, New York
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Nhat Hoang
aFrom the Department of Imaging Sciences (D.S., A.F., N.H., G.S., J.Z.), University of Rochester Medical Center, Rochester, New York
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Matthew T. Bender
bDepartment of Neurosurgery (M.T.B.), University of Rochester Medical Center, Rochester, New York
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Giovanni Schifitto
aFrom the Department of Imaging Sciences (D.S., A.F., N.H., G.S., J.Z.), University of Rochester Medical Center, Rochester, New York
cDepartment of Neurology (G.S.), University of Rochester Medical Center, Rochester, New York
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Jianhui Zhong
aFrom the Department of Imaging Sciences (D.S., A.F., N.H., G.S., J.Z.), University of Rochester Medical Center, Rochester, New York
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Article Information

vol. 45 no. 2 149-154
DOI 
https://doi.org/10.3174/ajnr.A8088
PubMed 
38238097

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received August 14, 2023
  • Accepted after revision November 2, 2023
  • Published online February 7, 2024.

Copyright & Usage 
© 2024 by American Journal of Neuroradiology

Author Information

  1. Derrek Schartza,
  2. Alan Finkelsteina,
  3. Nhat Hoanga,
  4. Matthew T. Benderb,
  5. Giovanni Schifittoa,c and
  6. Jianhui Zhonga
  1. aFrom the Department of Imaging Sciences (D.S., A.F., N.H., G.S., J.Z.), University of Rochester Medical Center, Rochester, New York
  2. bDepartment of Neurosurgery (M.T.B.), University of Rochester Medical Center, Rochester, New York
  3. cDepartment of Neurology (G.S.), University of Rochester Medical Center, Rochester, New York
  1. Please address correspondence to Derrek Schartz, MD, Department of Imaging Sciences, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642; e-mail: derrek_schartz{at}urmc.rochester.edu; @D_SchartzMD
View Full Text

Funding

  • Department of Imaging Sciences, University of Rochester

    Fischer Fund Grant
  • National Institute of Mental Health

    R01AG054328; R01MH118020

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Cited By...

  • 12 Citations
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This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Regulation of brain fluid volumes and pressures: basic principles, intracranial hypertension, ventriculomegaly and hydrocephalus
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  • Association of Extent of Transverse Sinus Stenosis With Cerebral Glymphatic Clearance in Patients With Idiopathic Intracranial Hypertension
    Derrek Schartz, Alan Finkelstein, Matthew Bender, Alex Kessler, Jianhui Zhong
    Neurology 2024 103 1
  • Total brain volume is associated with severity of transverse sinus stenosis in idiopathic intracranial hypertension
    Derrek Schartz, Alan Finkelstein, Sajal Medha K Akkipeddi, Alex Kessler, Zoe Williams, Edward Vates, Erik F Hauck, Kyle M Fargen, Matthew T Bender
    Journal of NeuroInterventional Surgery 2024
  • Improved Cerebral Glymphatic Flow after Transvenous Embolization of CSF-Venous Fistula
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    American Journal of Neuroradiology 2024 45 7
  • Current Understanding of the Pathophysiology of Idiopathic Intracranial Hypertension
    Michael Lowe, Gabriele Berman, Priya Sumithran, Susan P. Mollan
    Current Neurology and Neuroscience Reports 2025 25 1
  • Increased brain volume in idiopathic intracranial hypertension: Association with intracranial pressure and papilledema severity
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    Journal of the Neurological Sciences 2025 473
  • MRI Indices of Glymphatic Function Correlate With Disease Duration in Idiopathic Intracranial Hypertension
    Marc A. Bouffard, Mahsa Alborzi Avanaki, Jeremy N. Ford, Narjes Jaafar, Alexander Brook, Bardia Abbasi, Nurhan Torun, David Alsop, Donnella S. Comeau, Yu-Ming Chang
    Journal of Neuro-Ophthalmology 2024
  • Optic Nerve Sheath Dilation Is a Possible Marker of CSF Dyshomeostasis in Idiopathic Intracranial Hypertension
    Derrek Schartz, Alan J. Finkelstein, Emily Schartz, Saanya Lingineni, Matthew Sipple, Zoe Williams, Matthew T. Bender, Henry Wang
    Clinical Neuroradiology 2024
  • Outcomes of Pulsatile Tinnitus After Cerebral Venous Sinus Stenting: Systematic Review and Pooled Analysis of 616 Patients
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    World Neurosurgery 2024 190
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American Journal of Neuroradiology: 45 (2)
American Journal of Neuroradiology
Vol. 45, Issue 2
1 Feb 2024
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Cite this article
Derrek Schartz, Alan Finkelstein, Nhat Hoang, Matthew T. Bender, Giovanni Schifitto, Jianhui Zhong
Diffusion-Weighted Imaging Reveals Impaired Glymphatic Clearance in Idiopathic Intracranial Hypertension
American Journal of Neuroradiology Feb 2024, 45 (2) 149-154; DOI: 10.3174/ajnr.A8088

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Impaired Glymphatic Clearance in SIH
Derrek Schartz, Alan Finkelstein, Nhat Hoang, Matthew T. Bender, Giovanni Schifitto, Jianhui Zhong
American Journal of Neuroradiology Feb 2024, 45 (2) 149-154; DOI: 10.3174/ajnr.A8088
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Cited By...

  • Total brain volume is associated with severity of transverse sinus stenosis in idiopathic intracranial hypertension
  • Glymphatic Flow after Thrombectomy is Associated with Futile Recanalization in Large Vessel Occlusion Stroke
  • Improved Cerebral Glymphatic Flow after Transvenous Embolization of CSF-Venous Fistula
  • Crossref (12)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Regulation of brain fluid volumes and pressures: basic principles, intracranial hypertension, ventriculomegaly and hydrocephalus
    Stephen B. Hladky, Margery A. Barrand
    Fluids and Barriers of the CNS 2024 21 1
  • Association of Extent of Transverse Sinus Stenosis With Cerebral Glymphatic Clearance in Patients With Idiopathic Intracranial Hypertension
    Derrek Schartz, Alan Finkelstein, Matthew Bender, Alex Kessler, Jianhui Zhong
    Neurology 2024 103 1
  • Total brain volume is associated with severity of transverse sinus stenosis in idiopathic intracranial hypertension
    Derrek Schartz, Alan Finkelstein, Sajal Medha K Akkipeddi, Alex Kessler, Zoe Williams, Edward Vates, Erik F Hauck, Kyle M Fargen, Matthew T Bender
    Journal of NeuroInterventional Surgery 2024
  • Improved Cerebral Glymphatic Flow after Transvenous Embolization of CSF-Venous Fistula
    Derrek Schartz, Alan Finkelstein, Jianhui Zhong, Waleed Brinjikji, Matthew T. Bender
    American Journal of Neuroradiology 2024 45 7
  • Current Understanding of the Pathophysiology of Idiopathic Intracranial Hypertension
    Michael Lowe, Gabriele Berman, Priya Sumithran, Susan P. Mollan
    Current Neurology and Neuroscience Reports 2025 25 1
  • Increased brain volume in idiopathic intracranial hypertension: Association with intracranial pressure and papilledema severity
    Derrek Schartz, Alan Finkelstein, Jianhui Zhong, Matthew T. Bender
    Journal of the Neurological Sciences 2025 473
  • MRI Indices of Glymphatic Function Correlate With Disease Duration in Idiopathic Intracranial Hypertension
    Marc A. Bouffard, Mahsa Alborzi Avanaki, Jeremy N. Ford, Narjes Jaafar, Alexander Brook, Bardia Abbasi, Nurhan Torun, David Alsop, Donnella S. Comeau, Yu-Ming Chang
    Journal of Neuro-Ophthalmology 2024
  • Optic Nerve Sheath Dilation Is a Possible Marker of CSF Dyshomeostasis in Idiopathic Intracranial Hypertension
    Derrek Schartz, Alan J. Finkelstein, Emily Schartz, Saanya Lingineni, Matthew Sipple, Zoe Williams, Matthew T. Bender, Henry Wang
    Clinical Neuroradiology 2024
  • Outcomes of Pulsatile Tinnitus After Cerebral Venous Sinus Stenting: Systematic Review and Pooled Analysis of 616 Patients
    Derrek Schartz, Alan Finkelstein, Sajal Medha K. Akkipeddi, Zoe Williams, Edward Vates, Matthew T. Bender
    World Neurosurgery 2024 190
  • Radiopaedia.org
    Frank Gaillard, Rohit Sharma, Daniel Bell
    2015

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