Improved Detection of Target Metabolites in Brain Tumors with Intermediate TE, High SNR, and High Bandwidth Spin-Echo Sequence at 5T

A 43-year-old woman with a mass located in the left frontal lobe, suggesting a meningioma. It was an atypical meningioma (World Health Organization grade II) with invasion into the brain parenchyma. The HISE technique observed relatively strong Ala signal, while the PRESS technique could not differentiate between the Ala and Lac peaks. Both HISE and PRESS did not detect Lip signals. The yellow box in anatomical images represented the region of the volume of the SVS scan.

A 67 -year-old woman with a mass in the left temporal lobe with surrounding edema. On the basis of multimodal MR imaging, a high-grade glioma was suspected. Clinical correlation was recommended. The glioma was classified as a glioblastoma (World Health Organization grade IV, IDH1 wild-type). In the HISE, a Lac signal was detected. In PRESS, due to chemical shift displacement effects, a Lip signal originating from the scalp was detected, and the Lac signal was covered by the Lip signal. The yellow box in anatomical images represented the region of the volume of the SVS scan.

A 52-year-old man with a right occipital lobe space-occupying lesion, which was classified as a brain metastasis (originating from lung cancer). In the HISE, both Lac and Lip signals were detected. In PRESS, only a Lip signal was detected, and the Lac signal was covered by the Lip signal. The yellow box in anatomical images represented the region of the volume of the SVS scan.