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Case of the Week

Section Editors: Matylda Machnowska1 and Anvita Pauranik2
1University of Toronto, Toronto, Ontario, Canada
2BC Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada

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December 11, 2014

Squamous Cell Carcinoma

  • Squamous cell carcinoma is the most common skin tumor in oculocutaenous albinism patients. Basal cell carcinoma is also a common skin tumor in these patients.
  • Clinical Presentation: Skin masses
  • Key Diagnostic Features:
    • Large, heterogeneous, exophytic enhancing masses
    • Mass effect
    • Bony remodeling
    • Bony destruction not very common
    • Associated lymphadenopathy
  • DDx:
    • Metastases
    • Basal cell carcinoma
    • Fungal infections
    • Lymphoma
  • Rx: Palliative radiation therapy

Suggested Reading

Silverberg PPK, et al. Cutaneous malignancy in albinism. Cutis 2001;67:427–30

Matthieson C, Thompson S, Ahmad S, et al. Using an advanced radiation therapy technique for T4 squamous cell carcinoma of the face. J Dermatol Case Rep 2010;4:47–49, 10.3315/jdcr.2010.1051

Price KAR, Cohen EE. Current treatment options for metastatic head and neck cancer. Curr Treat Options Oncol 2012;13:35–46, 10.1007/s11864-011-0176-y

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