Article Figures & Data
Figures
- Fig 1.
Day 90 modified Rankin scores in patients aged ≥80 years versus younger patients.
- Fig 2.
Day 90 modified Rankin scores by age quartiles.
Tables
- Table 1:
Baseline characteristics of patients with acute ischemic stroke treated with IA thrombolysis
Variable Age <80 years (n = 81) Age ≥80 years (n = 33) Mean age (range), years 64 (25–79) 86 (80–97) Female, n (%) 38 (47%) 20 (61%) Current tobacco use, n (%) 19 (23%) 7 (21%) Hypertension, n (%) 58 (72%) 19 (58%) Diabetes mellitus, n (%) 13 (16%) 4 (12%) Hyperlipidemia, n (%) 27 (33%) 9 (27%) Coronary artery disease, n (%) 25 (31%) 10 (30%) Medium risk cardioembolic source, n (%) 11 (14%) 4 (12%) High-risk cardioembolic source, n (%) 39 (48%) 20 (61%) Prior stroke/TIA, n (%) 17 (21%)* 14 (42%)* Peripheral vascular disease, n (%) 2 (2%) 3 (1%) Antiplatelet therapy, n (%) 31 (38%) 10 (30%) Warfarin therapy, n (%) 11 (14%) 7 (21%) Weight, kg, mean ± SD 75.8 ± 13.0* 66.8 ± 10.8* BP peak pretreatment, mm Hg, mean ± SD Systolic 160 ± 30 168 ± 38 Diastolic 86 ± 18 92 ± 22 Glucose, mg/dL, mean ± SD 149 ± 46 146 ± 96 Platelets, ×103/μL, mean ± SD 233 ± 83 225 ± 68 Pretreatment NIHSS score, median (range) 16 (2–38) 17 (2–25) Presence of hyperdense MCA sign, n (%) 15 (19%) 5 (15%) Pathogenic mechanism Cardioembolic, n (%) 25 (31%) 12 (36%) Noncardioembolic, n (%) 37 (46%) 16 (48%) Undetermined, n (%) 19 (23%) 5 (16%) Location: anterior circulation, n (%) 67 (83%) 29 (88%) Target vessel localization, n (%) Extracranial internal carotid artery 12 (15%) 2 (6%) Intracranial internal carotid artery 10 (12%) 5 (15%) Both intracranial and extracranial internal carotid artery 1 (1%) 0 (0%) Middle cerebral artery 44 (54%) 17 (52%) Anterior cerebral artery 4 (5%) 2 (6%) Posterior cerebral artery 5 (5%) 1 (3%) Vertebrobasilar 11 (14%) 4 (12%) Note:—IA indicates intra-arterial; TIA, transient ischemic attack; BP, blood pressure; NIHSS, National Institutes of Health Stroke Scale; MCA, middle cerebral artery.
* P ≤ 0.05
- Table 2:
Treatment variables of patients with acute ischemic stroke treated with IA thrombolysis
Variable Age <80 years (n = 81) Age ≥80 years (n = 33) BP peak, intraprocedural, mm Hg, mean ± SD Systolic 170 ± 21 180 ± 23 Diastolic 92 ± 17 92 ± 16 Time from onset to start of IA infusion, min, mean ± SD 261 ± 150 257 ± 125 Time from onset to start of IA infusion 0–180 minutes, % 22% 12% Time from onset to start of IA infusion 181–360 minutes, % 70% 67% Time from onset to start of IA infusion >360 minutes, % 8% 21% Time from onset to end of procedure, min, mean ± SD 334 ± 150 336 ± 128 Treatment regimen, n (%) IA urokinase alone 33 (41%) 15 (45%) IA tPA alone 44 (54%) 15 (45%) IV/IA tPA 4 (5%) 3 (10%) Total IA tPA dose, mg, mean ± SD* 16.8 ± 10.5 17.2 ± 10.0 Note:—IA indicates intra-arterial; IV, intravenous; tPA, tissue plasminogen activator; BP, blood pressure.
* In patients receiving IA tPA
Age <80 years Age ≥80 years Cerebral, n (%) 30 (37%) 13 (39%) Asymptomatic, n (%) 19 (23%) 4 (18%) Minor symptomatic, n (%) 5 (6%) 5 (15%) Major symptomatic, n (%) 6 (7%) 2 (7%) Lobar, n (%) 12 (15%) 6 (19%) Deep, n (%) 14 (17%) 7 (23%) Within infarct territory, n (%) 26 (32%) 10 (30%) Outside infarct territory, n (%) 4 (5%) 3 (10%) Systemic, n (%) 1 (1%) 0 (0%) - Table 4:
Multivariate predictors of good functional outcome (mRS 0–2) (with age as a continuous variable)
OR CI P NIHSS score at presentation 0.858 0.781–0.942 .001 Age (per year) 0.949 0.909–0.991 .018 Highest systolic blood pressure during treatment 0.978 0.960–0997 .025 History of prior stroke/TIA 0.315 0.088–1.128 .076 Warfarin use 4.190 0.827–21.227 .076 Note:—mRS indicates modified Rankin Scale; OR, odds ratio; CI, confidence interval; NIHSS, National Institutes of Health Stroke Scale; TIA, transient ischemic attack.
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