Research ArticleINTERVENTIONAL
Intra-Arterial Thrombolysis for Acute Stroke in Patients 80 and Older: A Comparison of Results in Patients Younger than 80 Years
D. Kim, G.A. Ford, C.S. Kidwell, S. Starkman, F. Vinuela, G.R. Duckwiler, R. Jahan and J.L. Saver for the UCLA Intra-Arterial Thrombolysis Investigators
American Journal of Neuroradiology January 2007, 28 (1) 159-163;
D. Kim
G.A. Ford
C.S. Kidwell
S. Starkman
F. Vinuela
G.R. Duckwiler
R. Jahan

References
- ↵Brown RD, Whisnant JP, Sicks JD, et al. Stroke incidence, prevalence and survival: secular trends in Rochester, Minnesota, through 1989. Stroke 1996;27:373–80
- Wolf PA, D’Agostino RB, Belanger AJ, et al. Probability of stroke: a stroke profile from the Framingham study. Stroke 1991;22:312–18
- ↵Manolio TA, Kronmal RA, Burke GL, et al. Short-term predictors of incident stroke in older adults: the cardiovascular health study. Stroke 1996 :1479–86
- ↵Day J. Population projections of the United States by age, sex, race and Hispanic origin: 1995 to 2050. Current Population Reports, series P25–1130. Washington DC: US Bureau of the Census;1996 .
- ↵Smith D. The elderly population. In: Population Profile of the United States: 1997. Current Population Reports, series P23–194. Washington DC: US Bureau of the Census;1998 :50–52
- ↵del Zoppo GJ, Higashida RT, Furlan AJ, et al. PROACT: a phase II randomized trial of recombinant pro-urokinase by direct arterial delivery in acute middle cerebral artery stroke. PROACT Investigators. Prolyse in Acute Cerebral Thromboembolism. Stroke 1998;29:4–11
- ↵Furlan A, Higashida R, Wechsler L, et al. Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism. JAMA 1999;282:2003–11
- ↵Tanne D, Gorman M, Bates V, et al. Intravenous tissue plasminogen activator for acute ischemic stroke in patients aged 80 years and older: The TPA stroke survey experience. Stroke 2000;31:370–75
- Simon J, Sandler D, Pexman J, et al. Is intravenous recombinant tissue plasminogen activator (rt-PA) safe for use in patients over 80 years with acute ischaemic stroke?—The Calgary experience. Age Ageing 2004;33:143–49
- ↵Vatankhah B, Dittmar M, Fehm N, et al. Thrombolysis for stroke in the elderly. J Thromb Thrombolysis 2005;20:5–10
- ↵Kidwell CS, Saver JL, Carneado J, et al. Predictors of hemorrhagic transformation in patients receiving intra-arterial thrombolysis. Stroke 2002;33:717–24
- ↵Anonymous. The Thrombolysis in Myocardial Infarction (TIMI) trial. Phase I findings. TIMI Study Group. N Engl J Med 1985;312:932–36
- ↵Mori E, Yoneda Y, Tabuchi M, et al. Intravenous recombinant tissue plasminogen activator in acute carotid artery territory stroke. Neurology 1992;42:976–82
- ↵Anonymous. Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med 1995;333:1581–87
- ↵Arnold M, Schroth G, Nedeltchev K, et al. Intra-arterial thrombolysis in 100 patients with acute stroke due to middle cerebral artery occlusion. Stroke 2002;33:1828–33
- ↵Meade T, North W, Chakrabarti R, et al. Population-based distributions of haemostatic variables. Br Med Bull 1977;33:283–88
- ↵Bauer K, Weiss L, Sparrow D, et al. Aging-associated changes in indices of thrombin generation and protein C activation in humans: normative aging study. J Clin Invest 1987;80:1527–34
- Sakkinen P, Cushman M, Psaty B, et al. Correlates of antithrombin, protein C, protein S, and TFPI in a healthy elderly cohort. Thromb Haemost 1998;80:134–39
- ↵Gleerup G, Winther K. The effect of ageing on platelet function and fibrinolytic activity. Angiology 1995;46:715–18
- ↵Greenberg S, Vonsattel J. Diagnosis of cerebral amyloid angiopathy: sensitivity and specificity of cortical biopsy. Stroke 1997;28:1418–22
- ↵de Boer A, Kluft C, Kroon J, et al. Liver blood flow as a major determinant of the clearance of recombinant human tissue-type plasminogen activator. Thromb Haemost 1992;67:83–87
- ↵Tanne D, Kasner SE, Demchuk AM, et al. Markers of increased risk of intracerebral hemorrhage after intravenous recombinant tissue plasminogen activator therapy for acute ischemic stroke in clinical practice: the multicenter rT-PA stroke survey. Circulation 2002;105:1679–85
- Larrue V, von Kummer RR, Muller A, et al. Risk factors for severe hemorrhagic transformation in ischemic stroke patients treated with recombinant tissue plasminogen activator: a secondary analysis of the European-Australasian Acute Stroke Study (ECASS II). Stroke 2001;32:438–41
- ↵Gurwitz J, Gore J, Goldberg R, et al. Risk for intracranial hemorrhage after issue plasminogen activator treatment for acute myocardial infarction. Participants in the national registry of myocardial infarction 2. Ann Intern Med 1998;129:597–604
- ↵Kase C, Furlan A, Wechsler L, et al. Cerebral hemorrhage after intra-arterial thrombolysis for ischemic stroke: The PROACT II trial. Neurology 2001;57:1603–10
- ↵Asplund K, Carlberg B, Sundström G. Stroke in the elderly: observations in a population-based sample of hospitalized patients. Cerebrovasc Dis 1992;12:152–57
- Al Rajeh S. Stroke in the elderly aged 75 years and above. Cerebrovasc Dis 1994;4:402–06
- ↵Sharma JC, Fletcher S, Vassallo M. Strokes in the elderly–higher acute and 3 month mortality—an explanation. Cerebrovasc Dis 1999;9:2–9
- ↵Samsa G, Matchar D, Goldstein L, et al. Utilities for major stroke: Results from a survey of preferences among persons at increased risk for stroke. Am Heart J 1998;136:703–13
In this issue
Advertisement
D. Kim, G.A. Ford, C.S. Kidwell, S. Starkman, F. Vinuela, G.R. Duckwiler, R. Jahan, J.L. Saver
Intra-Arterial Thrombolysis for Acute Stroke in Patients 80 and Older: A Comparison of Results in Patients Younger than 80 Years
American Journal of Neuroradiology Jan 2007, 28 (1) 159-163;
0 Responses
Jump to section
Related Articles
- No related articles found.
Cited By...
- Sex differences in Cerebral Small Vessel Disease: a systematic review and meta-analysis
- Discrepancy between early neurological course and mid-term outcome in older stroke patients after mechanical thrombectomy
- Efficacy of endovascular stroke management in elderly patients
- Efficacy of intra-arterial therapy in the elderly requires further study
- Influence of Age on Clinical and Revascularization Outcomes in the North American Solitaire Stent-Retriever Acute Stroke Registry
- Optimizing Prediction Scores for Poor Outcome After Intra-Arterial Therapy in Anterior Circulation Acute Ischemic Stroke
- Multimodal endovascular management of acute ischemic stroke in patients over 75 years old is safe and effective
- Interaction of age with the ischaemic penumbra, leptomeningeal collateral circulation and haemodynamic variables in acute stroke: a pilot study
- Impact of Acute Ischemic Stroke Treatment in Patients >80 Years of Age: The Specialized Program of Translational Research in Acute Stroke (SPOTRIAS) Consortium Experience
- Elderly Patients Are at Higher Risk for Poor Outcomes After Intra-Arterial Therapy
- Centenarian middle cerebral artery occlusion treated with intra-arterial mechanical embolectomy
- Multimodal Reperfusion Therapy for Large Hemispheric Infarcts in Octogenarians: Is Good Outcome a Realistic Goal?
- Interventional Stroke Therapies in the Elderly: Are We Helping?
- Selecting stroke patients for intra-arterial therapy
- Angiographically documented hemorrhagic conversion of a left middle cerebral artery embolic stroke during intra-arterial thrombolysis
- Intravenous Alteplase for Stroke in Those Older Than 80 Years Old
- Occurrence and Predictors of Futile Recanalization following Endovascular Treatment among Patients with Acute Ischemic Stroke: A Multicenter Study
- Intra-Arterial Recanalization Techniques for Patients 80 Years or Older with Acute Ischemic Stroke: Pooled Analysis from 4 Prospective Studies
- Identifying Patients at High Risk for Poor Outcome After Intra-Arterial Therapy for Acute Ischemic Stroke
- Intra-Arterial Stroke Therapy: An Assessment of Demand and Available Work Force
- Haemorrhagic transformation in acute ischaemic stroke following thrombolysis therapy: classification, pathogenesis and risk factors
This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.
More in this TOC Section
Similar Articles
Advertisement