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Research ArticlePEDIATRICS

Angiography of Primary Central Nervous System Angiitis of Childhood: Conventional Angiography versus Magnetic Resonance Angiography at Presentation

R.I. Aviv, S.M. Benseler, G. DeVeber, E.D. Silverman, P.N. Tyrrell, L.M. Tsang and D. Armstrong
American Journal of Neuroradiology January 2007, 28 (1) 9-15;
R.I. Aviv
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S.M. Benseler
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G. DeVeber
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E.D. Silverman
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P.N. Tyrrell
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L.M. Tsang
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D. Armstrong
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  • Fig 1.
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    Fig 1.

    Representative MRA and angiographic images. Aggressive appearing lesions were those that demonstrated multiple short segment irregularity with alternating narrowing and dilation (beading) (white arrow) (A) or multiple longer segmental narrowing with normal intervening vessel (black arrowheads) (B). Aneurysms (not shown) were included in this definition. Benign appearing lesions (C) had smooth (white arrows), often solitary, tapered (white arrowhead) narrowing that could be concentric or eccentric. Incidental hypoplasia of the ipsilateral A1 is noted.

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    Fig 2.

    Good agreement of CA (A) and (B) MRA for right ICA. Both modalities demonstrate tapered narrowing of the terminal carotid and proximal M1 and A1 (carotid terminus) with focal midM1 dilation and distal narrowing. Both modalities identify beading of the proximal A1 (black arrows).

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    Fig 3.

    Abnormal CA (A) in the context of normal MRA (B) in a patient with a lone focal stenosis of the left PcomA. No other CA abnormality was present. MR imaging was abnormal maintaining suspicion for vasculitis despite a negative MRA.

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    Fig 4.

    A, Occlusion of the P3 segment of the right PCA on TOF MRA (white arrowhead). Inferior temporal branches (white arrows) are slightly more prominent than on the contralateral side but B, extent of collaterals and reconstitution of the distal PCA (black arrow) best seen on CA.

Tables

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    Table 1:

    Demographic distribution of abnormality in patients with abnormal MRA and CA

    MRA Patients (%)CA Patients (%)P Value
    Unilateral lesions*19 (79.2)19 (90.5)1.0
    Bilateral lesions5 (20.8)2 (9.5).42
    Any proximal lesion† regardless of whether distal lesion22 (87.5)18 (85.7).28
    Distal lesion only2 (8.3)3 (14.3).18
    Anterior circulation only‡19 (79.2)15 (71.4).36
    Posterior circulation only2 (8.3)3 (14.3)1.00
    Anterior and posterior3 (12.5)3 (14.3)1.00
    Ipsilateral ≥ 2 lesions§16 (66.7)16 (76.2)1.00
    Total lesions ≥ 53 (12.5)4 (19.0).29
    Benign appearance19 (79.2)16 (76.2).50
    Aggressive appearance5 (20.8)5 (23.8)1.00
    • Note:— MRA indicates MR angiography; CA, conventional angiography. Twenty-one CA and 24 MRA studies were abnormal and compared in 25 patients.

    • * Unilateral vs bilateral, P <0.05.

    • † Proximal vs distal, P = .08.

    • ‡ Anterior vs posterior, P = .06.

    • § Multifocal vs unifocal, P = .09.

    • View popup
    Table 2:

    Distribution of lesions on MRA and CA

    LesionsMRA (n = 62)CA (n = 64)P Value
    ICA11 (17.7%)11 (17.5%).94
    ACA11 (17.7%)17 (27.0%).23
    MCA34 (54.8%)26 (41.3%).11
        M12416.10
        M2109.75
        M401.32
    PCA5 (8.1%)9 (14.3%).28
        P122.97
        P237.21
    Vertebrobasilar00
    Anterior choroidal00
    PcomA1 (1.6%)1 (1.6%).98
    • Note:— MRA indicates MR angiography; CA, conventional angiography; ICA, internal carotid artery; ACA, anterior cerebral artery; MCA, middle cerebral artery; PCA, posterior cerebral artery; PcomA, posterior communicating artery.

    • View popup
    Table 3:

    Morphology of CA and MRA stenoses

    MorphologyMRA (n = 56)CA (n = 54)P Value
    Smooth45 (80.4%)45 (83.3%).80
    Irregular11 (19.6%)9 (16.7%).80
    Concentric54 (96.4%)50 (92.6%).57
    Eccentric2 (3.6%)4 (7.4%).57
    Graduated11 (19.6%)11 (20.4%).95
    Single52 (92.9%)48 (88.9%).64
    Beading6 (10.7%)6 (11.1%).97
    Multiple2 (3.6%)6 (11.1%).33
    • Note:— CA indicates conventional angiography; MRA, MR angiography. Data exclude occlusions and aneurysms.

    • View popup
    Table 4:

    Vascular segmental location of MRA false-negatives

    LocationNumber (n = 19)
    A14 (21.1%)
    Cavernous carotid3 (15.8%)
    M12 (10.5%)
    M24 (21.1%)
    M41 (5.3%)
    P11 (5.3%)
    P21 (5.3%)
    PcomA1 (5.3%)
    Pericallosal2 (10.5%)
    • Note:— MRA indicates MR angiography; PcomA, posterior communicating artery.

    • View popup
    Table 5:

    Stenosis quantification

    CA StenosisNumber of Lesions on CAMRA Agreement LesionsMRA Falsely Upgraded LesionsMRA Falsely Downgraded LesionsMRA False-Negatives
    <50%204 (20%)7 (35%)9 (45%)
    50–<75%2512 (48%)6 (24%)1 (4%)6 (24%)
    75–99%97 (78%)1 (11%)1 (11%)
    100%81 (13%)4 (50%)3 (38%)
    • Note:— MRA indicates MR angiography; CA, conventional angiography. Total MRA agreement is 43 lesions, excluding 2 aneurysms. Number of lesions correctly graded or up- and downgraded by MRA when compared with CA (n = 62 CA lesions; excludes 2 aneurysms)

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American Journal of Neuroradiology: 28 (1)
American Journal of Neuroradiology
Vol. 28, Issue 1
January 2007
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Cite this article
R.I. Aviv, S.M. Benseler, G. DeVeber, E.D. Silverman, P.N. Tyrrell, L.M. Tsang, D. Armstrong
Angiography of Primary Central Nervous System Angiitis of Childhood: Conventional Angiography versus Magnetic Resonance Angiography at Presentation
American Journal of Neuroradiology Jan 2007, 28 (1) 9-15;

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Angiography of Primary Central Nervous System Angiitis of Childhood: Conventional Angiography versus Magnetic Resonance Angiography at Presentation
R.I. Aviv, S.M. Benseler, G. DeVeber, E.D. Silverman, P.N. Tyrrell, L.M. Tsang, D. Armstrong
American Journal of Neuroradiology Jan 2007, 28 (1) 9-15;
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