Trastuzumab (Herceptin)

J.J. Gemmete; S.K. Mukherji

doi:10.3174/ajnr.A2619

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Research ArticlePharmacology Vignette

Trastuzumab (Herceptin)

J.J. Gemmete and S.K. Mukherji

American Journal of Neuroradiology September 2011, 32 (8) 1373-1374; DOI: https://doi.org/10.3174/ajnr.A2619

J.J. Gemmete

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S.K. Mukherji

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Fig 1.
Schematic illustration showing the proposed mechanism of trastuzumab. Herceptin is a monoclonal antibody that binds to the extracellular portion of the HER2 gene, preventing dimerization and the cascade that leads to the expression of growth factors. It also induces apoptosis through antibody-dependent cellular cytotoxicity. Illustration by Carolyn Nowak.

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J.J. Gemmete, S.K. Mukherji

Trastuzumab (Herceptin)

American Journal of Neuroradiology Sep 2011, 32 (8) 1373-1374; DOI: 10.3174/ajnr.A2619

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Trastuzumab (Herceptin)

J.J. Gemmete, S.K. Mukherji

American Journal of Neuroradiology Sep 2011, 32 (8) 1373-1374; DOI: 10.3174/ajnr.A2619

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