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Research ArticleAdult Brain

Perfusion MRI-Based Fractional Tumor Burden Differentiates between Tumor and Treatment Effect in Recurrent Glioblastomas and Informs Clinical Decision-Making

M. Iv, X. Liu, J. Lavezo, A.J. Gentles, R. Ghanem, S. Lummus, D.E. Born, S.G. Soltys, S. Nagpal, R. Thomas, L. Recht and N. Fischbein
American Journal of Neuroradiology October 2019, 40 (10) 1649-1657; DOI: https://doi.org/10.3174/ajnr.A6211
M. Iv
aFrom the Departments of Neuroimaging and Neurointervention (M.I., N.F.)
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X. Liu
fDepartment of Neurosurgery (X.L.), Shengjing Hospital of China Medical University, Shenyang, China.
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J. Lavezo
bPathology (J.L., R.G., S.L., D.E.B.)
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A.J. Gentles
cMedicine (Biomedical Informatics Research) (A.J.G.)
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  • ORCID record for A.J. Gentles
R. Ghanem
bPathology (J.L., R.G., S.L., D.E.B.)
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S. Lummus
bPathology (J.L., R.G., S.L., D.E.B.)
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D.E. Born
bPathology (J.L., R.G., S.L., D.E.B.)
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S.G. Soltys
dRadiation Oncology (S.G.S.)
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S. Nagpal
eNeurology (Neuro-Oncology) (S.N., R.T., L.R.), Stanford University, Stanford, California
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R. Thomas
eNeurology (Neuro-Oncology) (S.N., R.T., L.R.), Stanford University, Stanford, California
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L. Recht
eNeurology (Neuro-Oncology) (S.N., R.T., L.R.), Stanford University, Stanford, California
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N. Fischbein
aFrom the Departments of Neuroimaging and Neurointervention (M.I., N.F.)
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Article Information

vol. 40 no. 10 1649-1657
DOI 
https://doi.org/10.3174/ajnr.A6211
PubMed 
31515215

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received May 9, 2019
  • Accepted after revision August 1, 2019
  • Published online October 8, 2019.

Copyright & Usage 
© 2019 by American Journal of Neuroradiology

Author Information

  1. M. Iva,
  2. X. Liuf,
  3. J. Lavezob,
  4. A.J. Gentlesc,
  5. R. Ghanemb,
  6. S. Lummusb,
  7. D.E. Bornb,
  8. S.G. Soltysd,
  9. S. Nagpale,
  10. R. Thomase,
  11. L. Rechte and
  12. N. Fischbeina
  1. aFrom the Departments of Neuroimaging and Neurointervention (M.I., N.F.)
  2. bPathology (J.L., R.G., S.L., D.E.B.)
  3. cMedicine (Biomedical Informatics Research) (A.J.G.)
  4. dRadiation Oncology (S.G.S.)
  5. eNeurology (Neuro-Oncology) (S.N., R.T., L.R.), Stanford University, Stanford, California
  6. fDepartment of Neurosurgery (X.L.), Shengjing Hospital of China Medical University, Shenyang, China.
  1. Please address correspondence to Michael Iv, MD, Stanford University Medical Center, Department of Radiology, 300 Pasteur Dr, Grant Bldg, Room S031E, Stanford, CA 94305; e-mail: miv{at}stanford.edu
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American Journal of Neuroradiology: 40 (10)
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M. Iv, X. Liu, J. Lavezo, A.J. Gentles, R. Ghanem, S. Lummus, D.E. Born, S.G. Soltys, S. Nagpal, R. Thomas, L. Recht, N. Fischbein
Perfusion MRI-Based Fractional Tumor Burden Differentiates between Tumor and Treatment Effect in Recurrent Glioblastomas and Informs Clinical Decision-Making
American Journal of Neuroradiology Oct 2019, 40 (10) 1649-1657; DOI: 10.3174/ajnr.A6211

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Perfusion MRI-Based Fractional Tumor Burden Differentiates between Tumor and Treatment Effect in Recurrent Glioblastomas and Informs Clinical Decision-Making
M. Iv, X. Liu, J. Lavezo, A.J. Gentles, R. Ghanem, S. Lummus, D.E. Born, S.G. Soltys, S. Nagpal, R. Thomas, L. Recht, N. Fischbein
American Journal of Neuroradiology Oct 2019, 40 (10) 1649-1657; DOI: 10.3174/ajnr.A6211
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Cited By...

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  • Arterial Spin-Labeling and DSC Perfusion Metrics Improve Agreement in Neuroradiologists Clinical Interpretations of Posttreatment High-Grade Glioma Surveillance MR Imaging--An Institutional Experience
  • DSC Perfusion MRI-Derived Fractional Tumor Burden and Relative CBV Differentiate Tumor Progression and Radiation Necrosis in Brain Metastases Treated with Stereotactic Radiosurgery
  • Performance of Standardized Relative CBV for Quantifying Regional Histologic Tumor Burden in Recurrent High-Grade Glioma: Comparison against Normalized Relative CBV Using Image-Localized Stereotactic Biopsies
  • Crossref (17)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • High-Grade Glioma Treatment Response Monitoring Biomarkers: A Position Statement on the Evidence Supporting the Use of Advanced MRI Techniques in the Clinic, and the Latest Bench-to-Bedside Developments. Part 1: Perfusion and Diffusion Techniques
    Otto M. Henriksen, María del Mar Álvarez-Torres, Patricia Figueiredo, Gilbert Hangel, Vera C. Keil, Ruben E. Nechifor, Frank Riemer, Kathleen M. Schmainda, Esther A. H. Warnert, Evita C. Wiegers, Thomas C. Booth
    Frontiers in Oncology 2022 12
  • Performance of Standardized Relative CBV for Quantifying Regional Histologic Tumor Burden in Recurrent High-Grade Glioma: Comparison against Normalized Relative CBV Using Image-Localized Stereotactic Biopsies
    J.M. Hoxworth, J.M. Eschbacher, A.C. Gonzales, K.W. Singleton, G.D. Leon, K.A. Smith, A.M. Stokes, Y. Zhou, G.L. Mazza, A.B. Porter, M.M. Mrugala, R.S. Zimmerman, B.R. Bendok, D.P. Patra, C. Krishna, J.L. Boxerman, L.C. Baxter, K.R. Swanson, C.C. Quarles, K.M. Schmainda, L.S. Hu
    American Journal of Neuroradiology 2020 41 3
  • Metabolic and physiologic magnetic resonance imaging in distinguishing true progression from pseudoprogression in patients with glioblastoma
    Sanjeev Chawla, Sultan Bukhari, Omar M. Afridi, Sumei Wang, Santosh K. Yadav, Hamed Akbari, Gaurav Verma, Kavindra Nath, Mohammad Haris, Stephen Bagley, Christos Davatzikos, Laurie A. Loevner, Suyash Mohan
    NMR in Biomedicine 2022 35 7
  • The Prognostic Value of ctDNA and bTMB on Immune Checkpoint Inhibitors in Human Cancer
    Jiayan Wei, Jia Feng, Yiming Weng, Zexi Xu, Yao Jin, Peiwei Wang, Xue Cui, Peng Ruan, Ruijun Luo, Na Li, Min Peng
    Frontiers in Oncology 2021 11
  • Conventional and Advanced Imaging Techniques in Post-treatment Glioma Imaging
    Anna Y. Li, Michael Iv
    Frontiers in Radiology 2022 2
  • DSC Perfusion MRI–Derived Fractional Tumor Burden and Relative CBV Differentiate Tumor Progression and Radiation Necrosis in Brain Metastases Treated with Stereotactic Radiosurgery
    F. Kuo, N.N. Ng, S. Nagpal, E.L. Pollom, S. Soltys, M. Hayden-Gephart, G. Li, D.E. Born, Michael
    American Journal of Neuroradiology 2022 43 5
  • Advanced MRI Protocols to Discriminate Glioma From Treatment Effects: State of the Art and Future Directions
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  • Tumor treating fields increases blood-brain barrier permeability and relative cerebral blood volume in patients with glioblastoma
    Michael Iv, Lewis Naya, Sajal Sanan, Samuel L Van Buskirk, Seema Nagpal, Reena P Thomas, Lawrence D Recht, Chirag B Patel
    The Neuroradiology Journal 2024 37 1
  • Identification of single-dose, dual-echo based CBV threshold for fractional tumor burden mapping in recurrent glioblastoma
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  • Case report: Fractional brain tumor burden magnetic resonance mapping to assess response to pulsed low-dose-rate radiotherapy in newly-diagnosed glioblastoma
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