Novel Human Acute Ischemic Stroke Blood Clot Analogs for In Vitro Thrombectomy Testing

S.T. Fitzgerald; Y. Liu; D. Dai; O.M. Mereuta; M. Abbasi; J.L.A. Larco; A.S. Douglas; D.F. Kallmes; L. Savastano; K.M. Doyle; W. Brinjikji

doi:10.3174/ajnr.A7102

Research ArticleInterventional

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Novel Human Acute Ischemic Stroke Blood Clot Analogs for In Vitro Thrombectomy Testing

S.T. Fitzgerald, Y. Liu, D. Dai, O.M. Mereuta, M. Abbasi, J.L.A. Larco, A.S. Douglas, D.F. Kallmes, L. Savastano, K.M. Doyle and W. Brinjikji

American Journal of Neuroradiology July 2021, 42 (7) 1250-1257; DOI: https://doi.org/10.3174/ajnr.A7102

S.T. Fitzgerald

aFrom the Departments of Radiology (S.T.F., Y.L., D.D., O.M.M., M.A., D.F.K., W.B.)

cDepartment of Physiology (S.T.F., O.M.M., A.S.D., K.M.D.)

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Y. Liu

aFrom the Departments of Radiology (S.T.F., Y.L., D.D., O.M.M., M.A., D.F.K., W.B.)

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D. Dai

aFrom the Departments of Radiology (S.T.F., Y.L., D.D., O.M.M., M.A., D.F.K., W.B.)

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O.M. Mereuta

aFrom the Departments of Radiology (S.T.F., Y.L., D.D., O.M.M., M.A., D.F.K., W.B.)

cDepartment of Physiology (S.T.F., O.M.M., A.S.D., K.M.D.)

dSFI Centre for Research in Medical Devices (O.M.M., A.S.D., K.M.D.), National University of Ireland Galway, Galway, Ireland

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M. Abbasi

aFrom the Departments of Radiology (S.T.F., Y.L., D.D., O.M.M., M.A., D.F.K., W.B.)

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J.L.A. Larco

bNeurosurgery (J.L.A.L., L.S., W.B.), Mayo Clinic, Rochester, Minnesota

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A.S. Douglas

cDepartment of Physiology (S.T.F., O.M.M., A.S.D., K.M.D.)

dSFI Centre for Research in Medical Devices (O.M.M., A.S.D., K.M.D.), National University of Ireland Galway, Galway, Ireland

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D.F. Kallmes

aFrom the Departments of Radiology (S.T.F., Y.L., D.D., O.M.M., M.A., D.F.K., W.B.)

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L. Savastano

bNeurosurgery (J.L.A.L., L.S., W.B.), Mayo Clinic, Rochester, Minnesota

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K.M. Doyle

cDepartment of Physiology (S.T.F., O.M.M., A.S.D., K.M.D.)

dSFI Centre for Research in Medical Devices (O.M.M., A.S.D., K.M.D.), National University of Ireland Galway, Galway, Ireland

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W. Brinjikji

aFrom the Departments of Radiology (S.T.F., Y.L., D.D., O.M.M., M.A., D.F.K., W.B.)

bNeurosurgery (J.L.A.L., L.S., W.B.), Mayo Clinic, Rochester, Minnesota

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Article Information

vol. 42 no. 7 1250-1257

DOI

https://doi.org/10.3174/ajnr.A7102

PubMed

33832952

Published By

American Journal of Neuroradiology

Print ISSN

0195-6108

Online ISSN

1936-959X

History

Received September 29, 2020
Accepted after revision January 26, 2021
Published online July 13, 2021.

Author Information

S.T. Fitzgeralda,c,
Y. Liua,
D. Daia,
O.M. Mereutaa,c,d,
M. Abbasia,
J.L.A. Larcob,
A.S. Douglasc,d,
D.F. Kallmesa,
L. Savastanob,
K.M. Doylec,d and
W. Brinjikjia,b

^aFrom the Departments of Radiology (S.T.F., Y.L., D.D., O.M.M., M.A., D.F.K., W.B.)
^bNeurosurgery (J.L.A.L., L.S., W.B.), Mayo Clinic, Rochester, Minnesota
^cDepartment of Physiology (S.T.F., O.M.M., A.S.D., K.M.D.)
^dSFI Centre for Research in Medical Devices (O.M.M., A.S.D., K.M.D.), National University of Ireland Galway, Galway, Ireland

Please address correspondence to Seán Fitzgerald, PhD, Department of Physiology, Human Biology Building, National University of Ireland Galway, Galway, H91 TK33, Ireland; e-mail: Sean.Fitzgerald{at}nuigalway.ie; @FitzSeanT; @WBrinjikji

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Funding

Enterprise Ireland
IP20190865
National Institutes of Health
R01 NS105853
European Regional Development Fund
13/RC/2073
Science Foundation Ireland
13/RC/2073

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S.T. Fitzgerald, Y. Liu, D. Dai, O.M. Mereuta, M. Abbasi, J.L.A. Larco, A.S. Douglas, D.F. Kallmes, L. Savastano, K.M. Doyle, W. Brinjikji

Novel Human Acute Ischemic Stroke Blood Clot Analogs for In Vitro Thrombectomy Testing

American Journal of Neuroradiology Jul 2021, 42 (7) 1250-1257; DOI: 10.3174/ajnr.A7102

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Novel Human Acute Ischemic Stroke Blood Clot Analogs for In Vitro Thrombectomy Testing

S.T. Fitzgerald, Y. Liu, D. Dai, O.M. Mereuta, M. Abbasi, J.L.A. Larco, A.S. Douglas, D.F. Kallmes, L. Savastano, K.M. Doyle, W. Brinjikji

American Journal of Neuroradiology Jul 2021, 42 (7) 1250-1257; DOI: 10.3174/ajnr.A7102

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Cited By...

An in vitro model for Extracellular DNA Traps (ETs)-rich Human Thrombus Analogs
An in vitro model for Extracellular DNA Traps (ETs)-rich Human Thrombus Analogs
A Thrombectomy Model Based on Ex Vivo Whole Human Brains

Crossref (22)
Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

Measuring the effect of thrombosis, thrombus maturation and thrombolysis on clot mechanical properties in an in-vitro model

Anushree Dwivedi, Aoife Glynn, Sarah Johnson, Sharon Duffy, Behrooz Fereidoonnezhad, Patrick McGarry, Michael Gilvarry, Ray McCarthy

Journal of Biomechanics 2021 129
Tensile and Compressive Mechanical Behaviour of Human Blood Clot Analogues

Rachel M. E. Cahalane, Judith J. de Vries, Moniek P. M. de Maat, Kim van Gaalen, Heleen M. van Beusekom, Aad van der Lugt, Behrooz Fereidoonnezhad, Ali C. Akyildiz, Frank J. H. Gijsen

Annals of Biomedical Engineering 2023 51 8
Effect of Chandler loop shear and tubing size on thrombus architecture

Ziqian Zeng, Tanmaye Nallan Chakravarthula, Alexei Christodoulides, Abigail Hall, Nathan J. Alves

Journal of Materials Science: Materials in Medicine 2023 34 5
MicroCT Can Characterize Clots Retrieved With Mechanical Thrombectomy From Acute Ischemic Stroke Patients–A Preliminary Report

Daniela Dumitriu LaGrange, Vincent Braunersreuther, Isabel Wanke, Jatta Berberat, Siri Luthman, Seán Fitzgerald, Karen M. Doyle, Olivier Brina, Philippe Reymond, Alexandra Platon, Michel Muster, Paolo Machi, Pierre-Alexandre Poletti, Maria Isabel Vargas, Karl-Olof Lövblad

Frontiers in Neurology 2022 13
Microemulsion-Inspired Polysaccharide Nanoparticles for an Advanced Targeted Thrombolytic Treatment

Thibault de La Taille, Pierre Sarfati, Rachida Aid, Louise Fournier, Graciela Pavon-Djavid, Frédéric Chaubet, Cédric Chauvierre

ACS Nano 2025 19 2
Dynamic Perviousness Predicts Revascularization Success in Acute Ischemic Stroke

Gergely Bertalan, Roxane Duparc, Miklos Krepuska, Daniel Toth, Jawid Madjidyar, Patrick Thurner, Tilman Schubert, Zsolt Kulcsar

Diagnostics 2024 14 5
Experimental Validation of Pullout Resistance for Stent Retrievers and Aspiration Catheters

Yujiro Tanaka, Yusuke Kanoko, Tomoya Yokoyama, Kohei Nakaya

Journal of Neuroendovascular Therapy 2022 16 9
Multimodality Characterization of the Clot in Acute Stroke

Daniela Dumitriu LaGrange, Isabel Wanke, Paolo Machi, Gianmarco Bernava, Maria Vargas, Daniele Botta, Jatta Berberat, Michel Muster, Alexandra Platon, Pierre-Alexandre Poletti, Karl-Olof Lövblad

Frontiers in Neurology 2021 12
In vitro models for the experimental evaluation of mechanical thrombectomy devices in acute ischemic stroke

Ronghui Liu, Hongping He, Luo Zhang, Yubo Fan, Jun Wang, Weidong Wang

Interventional Neuroradiology 2023 29 6
MicroCT and Histological Analysis of Clot Composition in Acute Ischemic Stroke

Briana A. Santo, TaJania D. Jenkins, Shiau-Sing K. Ciecierska, Ammad A. Baig, Elad I. Levy, Adnan H. Siddiqui, Vincent M. Tutino

Clinical Neuroradiology 2024 34 2

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Novel Human Acute Ischemic Stroke Blood Clot Analogs for In Vitro Thrombectomy Testing

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