Case of the Week
Section Editors: Matylda Machnowska1 and Anvita Pauranik2
1University of Toronto, Toronto, Ontario, Canada
2BC Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada
Sign up to receive an email alert when a new Case of the Week is posted.
June 6, 2019
Epidural Lipomatosis with Post-operative Cord Infarct
- Background
- Epidural lipomatosis is a rare condition due to overgrowth of adipose tissue in the extradural space, most commonly found in the thoracic spine.
- The underlying mechanism remains unknown, however 4 main underlying causes can be identified; the most prevalent being exogenous steroid use, but also includes endogenous elevation of steroids, obesity, and other idiopathic causes.
- Clinical Presentation
- Chronic back pain, gradual lower limb weakness, and neurological deficits related to local mass effect of lipomatosis and resultant spinal cord and/or nerve root compression.
- Key Diagnostic Features
- Epidural fat follows fat signal on all MR sequences, has homogeneous high signal intensity on T1- and T2-weighed images, with suppressed signal on STIR and fat-saturated MR images.
- Mean sagittal thickness of epidural fat greater than or equal to 7 mm is suggestive of epidural lipomatosis.
- Along the thoracic spine, fat is predominantly found dorsally with ventral displacement of the thecal sac.
- At the lumbar level, the fat is circumferential, with a trefoil or Y-shaped appearance.
- Differential Diagnosis (for epidural process)
- Subacute epidural hematoma: Can have similar MR appearance to epidural lipomatosis but use of fat-suppression techniques in conjunction with T1- and T2-weighted sequences can help differentiate. Acute epidural hemorrhage is isointense on T1-weighted MR images initially and later becomes hyperintense on T1- and T2-weighted MR images when subacute. Chronicity of symptoms with lack of trauma and negative coagulation panel is also more suggestive of epidural lipomatosis.
- Spinal lipoma/spinal angiolipoma: Encapsulated spinal lipoma occurs commonly in the thoracic spine within epidural space dorsal to thecal sac, and presents as a focal lesion without extension to adjacent vertebral levels whereas spinal angiolipoma can be composed of adipose and vascular elements with potential for invasion of surrounding structures, e.g. bone.
- Epidural tumor/metastases: Intermediate to high signal on T2WI and STIR with gadolinium enhancement. E.g. epidural liposcarcoma presents with irregular thickened septa on MR images which can enhance following contrast, with areas of hyperintense signal on T2-weighted MR.
- Differential Diagnosis (for extensive cord T2 hyperintensity)
- Cord ischemia/infarct: Abnormal T2 hyperintense signal within the cord, presenting as focal cord enlargement, without enhancement. While MR may be normal within first few hours after onset of symptoms, these delayed imaging findings are not uncommon and can appear several days post initial infarct.
- Demyelinating disease: Includes acute disseminated encephalomyelitis (ADEM) and transverse myelitis (TM). ADEM appears as areas of increased T2/FLAIR with edema and localized mass effect, with enhancement uncommon. TM appears hypo- or isointense on T1, hyperintense on T2, with variable enhancement.
- Type 1 dural AVF: Hyperintensities with peripheral sparing on T2WI with possible cord extension of 5-7 vertebral levels and conus involvement. Spinal cord edema in dural AVF is usually homogenous with a tapered margin. Dilated intervertebral vein or engorged venous flow voids on T2-weighted images are suggestive.
- Spinal cord intramedullary tumor (if timing applicable): Manifests as expansion of the cord with varying signal intensities and enhancement depending on the tumor type. In children, astrocytomas are most common type – they are ill defined, are T1 hypo- or isointense, T2 hyperintense. and have heterogeneous or no enhancement.
- Radiation myelopathy (if history applicable): Presents as swelling of the cord with T2 hyperintensity with or without areas of enhancement.
- Treatment
- Dependent on severity of symptoms, ranging from conservative therapy such as weight loss and steroid tapering, to more invasive interventions such as surgical decompression with multilevel laminectomy and fusion when there is cord compression and radiculopathy.
- A rare, post-surgical complication of such decompression includes cord ischemia/infarct, such as that seen in this case. Possible mechanisms for post-decompression cord infarct consist of, but are not limited to, reperfusion injury such as hypotension and/or sub-therapeutic MAP, intra-operative manipulation, epidural hematoma, hemorrhage, and persistent and/or new cord compression.
Current Issue
Case Collections
