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Research ArticlePEDIATRICS

Brain MR Spectroscopy Findings in Neonates with Hypothyroidism Born to Mothers Living in Iodine-Deficient Areas

A. Akinci, K. Sarac, S. Güngör, I. Mungan and Ö. Aydın
American Journal of Neuroradiology November 2006, 27 (10) 2083-2087;
A. Akinci
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K. Sarac
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S. Güngör
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I. Mungan
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Ö. Aydın
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References

  1. ↵
    Oklund S, Timiras PS. Influences of thyroid levels in brain ontogenesis in vivo and in vitro. In: Grave GD, ed. Thyroid Hormones and Brain Development. New York: Raven Press;1977;33–47
  2. ↵
    Morreale de Escobar G, Pastor R, Obregon MJ, et al. Effects of maternal hypothyroidism on the weight and thyroid hormone content of rat embryonic tissues, before and after onset of fetal thyroid function. Endocrinology 1985;117:1890–900
    CrossRefPubMedWeb of Science
  3. ↵
    Vulsma T, Gons MH, de Vijlder JJM. Maternal-fetal transfer of thyroxine in congenital hypothyroidism due to a total organification defect of thyroid agenesis. N Engl J Med 1989;321:13–16
    CrossRefPubMedWeb of Science
  4. ↵
    de Escobar GM, Obregon MJ, del Rey FE. Maternal thyroid hormones early in pregnancy and fetal brain development. Best Pract Res Clin Endocrinol Metab 2004;18:225–48
    CrossRefPubMed
  5. ↵
    de Escobar GM, Obregon MJ, del Rey FE. Is neurophysiological development related to maternal hypothyroidism or to maternal hypothyroxinemia? J Clin Endocrinol Metab 2000;85:3975–87
    CrossRefPubMedWeb of Science
  6. ↵
    Martin E, Keller M, Ritter S, et al. Contribution of proton magnetic resonance spectroscopy to the evaluation of children with unexplained developmental delay. Pediatr Res 2005;58:754–60
    CrossRefPubMed
  7. ↵
    Gujar SK, Maheshwari S, Bjorkman-Burtscher I, et al. Magnetic resonance spectroscopy. J Neuroophthalmol 2005;25:217–26
    PubMed
  8. ↵
    Baslow MH. Functions of N-acetyl-L-aspartate and N-axetyl-L-aspartylglutamate in the vertebrate brain: role in glial cell-specific signaling. J Neurochem 2000;75:453–59
    CrossRefPubMedWeb of Science
  9. ↵
    Larson HBW, Christiansen P, Jensen M, et al. Localized in vivo proton spectroscopy in the brain of patients with multiple sclerosis. Magn Reson Med 1991;22:23–31
    PubMedWeb of Science
  10. ↵
    Simsek E, Karabay M, Kocabay K. Neonatal screening for congenital hypothyroidism in West Black Sea area, Turkey. Int J Clinical Pract 2005;59:336–41
  11. ↵
    American Academy of Pediatrics AAP Section on Endocrinology and Committee on Genetics, and American Thyroid Association Committee on Public Health: newborn screening for congenital hypothyroidism—recommended guidelines. Pediatrics 1993;91:1203–09
    Abstract/FREE Full Text
  12. ↵
    Dunn JT, Crutchfield HE, Gutekunst R, et al. Two simple methods for measuring iodine in urine. Thyroid 1993;3:119–23
    CrossRefPubMedWeb of Science
  13. ↵
    WHO/UNICEF/ICCD. Indicators for assessing iodine deficiency disorders and their control through salt iodization. WHO/NUT/94.6. Geneva, Switzerland: WHO;1994
  14. ↵
    Vitti P, Martino E, Aghini-Lombardi F, et al. Thyroid volume measurement by ultrasound in children as a tool for the assessment of mild iodine deficiency. J Clin Endocrinol Metab 1994;79:600–03
    CrossRefPubMedWeb of Science
  15. ↵
    Bergout A, Endert E, Ross A, et al. Thyroid function and thyroid size in normal and pregnant women living in an iodine replete area. Clin Endocrinol (Oxf) 1994;41:375–79
    PubMed
  16. ↵
    Kung AWD, Lao TT, Chau MT, et al. Goitrogenesis during a pregnancy and neonatal hypothyroxinaemia in a borderline iodine sufficient area. Clin Endocrinol (Oxf) 2000;53:725–31
    CrossRefPubMed
  17. ↵
    Pharoah P, Connely K, Hetzel B, et al. Maternal thyroid function and motor competence in the child. Dev Med Child Neurol 1981;23:76–82
    PubMedWeb of Science
  18. ↵
    Porterfield SP, Hendrich CE. The role of thyroid hormones in parental and neonatal neurological development: current perspectives. Endocr Rev 1993;14:94–106
    CrossRefPubMedWeb of Science
  19. ↵
    Cecil KM, Jones BV. Magnetic resonance spectroscopy of the pediatric brain. Top Magn Reson Imaging 2001;12:435–52
    CrossRefPubMed
  20. ↵
    Bates TE, Strangward M, Keelan J, et al. Inhibition of N-acetyl aspartate production: implications for H MRS studies in vivo. Neuroreport 1996;7:1397–400
    CrossRefPubMedWeb of Science
  21. ↵
    Demougeot C, Garnier P, Mossiat C, et al. N-acetylaspartate, a marker of both cellular dysfunction and neuronal loss: its relevance to studies of acute brain injury. J Neurochem 2001;7:408–15
  22. ↵
    Pouwels PJ, Brockmann K, Kruse B, et al. Regional age dependence of human brain metabolites from infancy to adulthood as detected by quantitative localized proton MRS. Pediatr Res 1999;46:474–85
    CrossRefPubMedWeb of Science
  23. ↵
    Horska A, Kaufmann WE, Brant LJ, et al. In vivo quantitative proton MRSI study of brain development from childhood to adolescence. J Magn Reson Imaging 2002;15:137–43
    CrossRefPubMedWeb of Science
  24. ↵
    Baslow MH. Brain N-acetyl-aspartate as a molecular water pump and its role in the etiology of Canavan disease: a mechanistic explanation. J Mol Neurosci 2003;21:185–90
    CrossRefPubMedWeb of Science
  25. ↵
    Jagannathan NR, Tandon N, Raghunathan P, et al. Reversal of abnormalities of myelination by thyroxine therapy in congenital hypothyroidism: localized in vivo proton magnetic resonance spectroscopy (MRS) study. Brain Res Dev Brain Res 1998;109:179–86
    CrossRefPubMed
  26. ↵
    Miller BL. A review of chemical issues in H-NMR spectroscopy: N-acetyl-L-aspartate, creatine and choline. NMR Biomed 1991;4:47–50
    CrossRefPubMedWeb of Science
  27. ↵
    Gupta RK, Bhatia V, Poptani H, et al. Brain metabolite changes on in vivo proton magnetic resonance spectroscopy in children with congenital hypothyroidism. J Pediatr 1995;126:389–92
    CrossRefPubMed
  28. ↵
    Sugie H, Tsurui S, Ishikawa A, et al. Effects of neonatal hypothyroidism on brain development: analysis of brain metabolites using high resolution phosphorus and proton magnetic resonance (NMR) spectroscopy [in Japansese]. No To Hattatsu 1990;22:166–72
    PubMed
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American Journal of Neuroradiology: 27 (10)
American Journal of Neuroradiology
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A. Akinci, K. Sarac, S. Güngör, I. Mungan, Ö. Aydın
Brain MR Spectroscopy Findings in Neonates with Hypothyroidism Born to Mothers Living in Iodine-Deficient Areas
American Journal of Neuroradiology Nov 2006, 27 (10) 2083-2087;

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Brain MR Spectroscopy Findings in Neonates with Hypothyroidism Born to Mothers Living in Iodine-Deficient Areas
A. Akinci, K. Sarac, S. Güngör, I. Mungan, Ö. Aydın
American Journal of Neuroradiology Nov 2006, 27 (10) 2083-2087;
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