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Research ArticleAdult Brain

Molecular Subtype Classification in Lower-Grade Glioma with Accelerated DTI

E. Aliotta, H. Nourzadeh, P.P. Batchala, D. Schiff, M.B. Lopes, J.T. Druzgal, S. Mukherjee and S.H. Patel
American Journal of Neuroradiology September 2019, 40 (9) 1458-1463; DOI: https://doi.org/10.3174/ajnr.A6162
E. Aliotta
aFrom the Departments of Radiation Oncology (E.A., H.N.)
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H. Nourzadeh
aFrom the Departments of Radiation Oncology (E.A., H.N.)
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P.P. Batchala
bRadiology (P.P.B., J.T.D., S.M., S.H.P.)
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D. Schiff
cNeurology (D.S.)
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M.B. Lopes
dPathology (Neuropathology) (M.B.L.), University of Virginia, Charlottesville, Virginia.
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J.T. Druzgal
bRadiology (P.P.B., J.T.D., S.M., S.H.P.)
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S. Mukherjee
bRadiology (P.P.B., J.T.D., S.M., S.H.P.)
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S.H. Patel
bRadiology (P.P.B., J.T.D., S.M., S.H.P.)
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    Fig 1.

    Patient population flow chart.

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    Fig 2.

    Sample T2-weighted images with tumor segmentations (A), ADC maps (B), FA maps (C), and dFA maps (D) from each LGG molecular subtype as well as mean ADC, FA, and dFA values (E) from these individual cases.

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    Fig 3.

    Boxplots showing mean ADC (A), FA (B), and dFA (C) values across LGG subtypes. Central lines indicate median values, box edges indicate 25th and 75th percentiles, and whiskers extend to the full data range, excluding outliers (which are indicated by plus signs). P values < 0.008 indicate statistically significant differences to account for multiple comparisons.

Tables

  • Figures
  • Features selected in the imbalance-adjusted bootstrap resampling process for each classification schemea

    Histogram and Texture Features
    ADCADC + FAADC + dFA
    FeatureWeightFeatureWeightFeatureWeight
    IDHWT vs IDHMUTADC 75%−6.5ADC 10%109.4ADC 10%40.4
    ADC 90%−71.4ADC homogeneity60.2
    ADC energy4363.0dFA energy−1459.0
    FA 75%227.5dFA skewness−6.45
    FA contrast24.2
    FA homogeneity−346.9
    IDHMUT-Codel vs IDHMUT-NoncodelADC 50%−10.7ADC 50%−266.8ADC 75%−62.9
    ADC 25%306.8ADC 10%40.0
    ADC skewness−17.9dFA 50%202.9
    FA 75%460.9dFA skewness11.9
    FA skewness−141.5
    • ↵a For IDHWT vs IDHMUT, positive values indicate positive correlations with IDHWT. For IDHMUT-Codel vs IDHMUT-Noncodel, positive values indicate positive correlations with IDHMUT-Noncodel. ADC units are in square millimeters/millisecond.

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American Journal of Neuroradiology: 40 (9)
American Journal of Neuroradiology
Vol. 40, Issue 9
1 Sep 2019
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Cite this article
E. Aliotta, H. Nourzadeh, P.P. Batchala, D. Schiff, M.B. Lopes, J.T. Druzgal, S. Mukherjee, S.H. Patel
Molecular Subtype Classification in Lower-Grade Glioma with Accelerated DTI
American Journal of Neuroradiology Sep 2019, 40 (9) 1458-1463; DOI: 10.3174/ajnr.A6162

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Molecular Subtype Classification in Lower-Grade Glioma with Accelerated DTI
E. Aliotta, H. Nourzadeh, P.P. Batchala, D. Schiff, M.B. Lopes, J.T. Druzgal, S. Mukherjee, S.H. Patel
American Journal of Neuroradiology Sep 2019, 40 (9) 1458-1463; DOI: 10.3174/ajnr.A6162
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